Indicators of angiogenesis and hormonal profile in pregnant women with chronic hypertension in the first trimester

The role of angiogenesis factors and hormonal profile in pregnant women with arterial hypertension has not been detailed studied, their interaction such patients determined at present time.The objective: to determine the features 1and 2 grade. Materials methods. A prospective study was conducted 88 women, which included: analysis clinical anamnestic characteristics pregnancy chronic (CAH) I trimester (11–12 weeks). open controlled involved 61 CAH 1 stages consisted main group. control group included 27 healthy physiological pregnancy. Concentrations human chorionic gonadotropin (hCG), progesterone (PG), estradiol (E) markers – placental growth factor (PlGF) as a proangiogenic soluble fms-like tyrosine kinase (sFlt-1) an antiangiogenic were blood serum all patients, sFlt-1/PGF ratio also estimated (K). Statistical performed using «STATISTICA® for Windows 13.0».Results. In CAH, shift balance between pro- anti-angiogenic is determined, manifested by statistically significant (p<0.05) increase sFlt-1 level (1700.9 pg/ml) decrease PlGF 3.7 times (9.1 and, accordingly, K coefficient (sFlt-1/PlGF) 5.3 (184.5). mean concentrations E, PG hCG did differ significantly from those However, according results correlation analysis, indicators have feedback (r=-0.29; p<0.05). When calculating hormones, it found that there group, namely indicator correlates (51.8 units vs. 14.8 units) 3.5 times, E (309.7 70.0 4.4 (4.8 1.0 4.8 (p<0.001 indicators). These changes indicate presence disorders hypertension, starting gestation.Conclusions. Pregnant disturbances pro-angiogenic prevalence serum. Because imbalance grade, hormones changed direct inverse. It may lead development dysfunction future, so treatment prevention should be provided trimester.